Welcome to
Sysmex Flow Cytometry Ireland!

For ordering please make sure you are in your local shop.
If you are from Ireland then please continue.
Otherwise please go to your country.

Go to my country Continue

Article successfully added.

CyFlow™ CD11a Azide Free

CyFlow™ CD11a Azide Free
Application: Flow cytometry, Functional assays, Immunoprecipitation
Clonality: monoclonal
Target Species: Human
Regulatory Status: RUO
Source Species: Mouse
Field of Interest: Immunophenotyping
Isotype: IgG1
Format/Fluorochrome: Azide Free
Antigen: CD11a
Alternative Name: LFA-1
Clone: MEM-25
Order number: AM553938
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
Product information "CyFlow™ CD11a Azide Free"
Concentration Unitmg/mL
Concentration1
Quantity0.1 mg
Volume0.1 mL
ImmunogenLeukocytes of a patient suffering from LGL-type leukemia
Background InformationCD11a (LFA-1 α) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the αLβ2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation; binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.
Storage BufferThe reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized.
StorageAvoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
StabilityDo not use after expiration date stamped on vial label.
Similar products
FITC
CyFlow™ CD1a FITC
Antigen: CD1a
Clone: SK9
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
PE
CyFlow™ CD1a PE
Antigen: CD1a
Clone: SK9
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
APC
CyFlow™ CD1a APC
Antigen: CD1a
Clone: SK9
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
Purified
CyFlow™ CD1a Purified
Antigen: CD1a
Clone: SK9
Application: Flow cytometry, Immunoprecipitation
Regulatory Status: RUO
Target Species: Human
Quantity: 0.1 mg
FITC
CyFlow™ CD1b FITC
Antigen: CD1b
Clone: SN13
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
Purified
CyFlow™ CD1b Purified
Antigen: CD1b
Clone: SN13
Application: Flow cytometry, Immunohistochemistry, Immunoprecipitation
Regulatory Status: RUO
Target Species: Human
Quantity: 0.1 mg
PE
CyFlow™ CD1c PE
Antigen: CD1c
Clone: L161
Application: Flow cytometry
Regulatory Status: RUO
Target Species: Human
Quantity: 100 tests
Purified
CyFlow™ CD1c Purified
Antigen: CD1c
Clone: L161
Application: Flow cytometry, Immunohistochemistry, Immunoprecipitation
Regulatory Status: RUO
Target Species: Human
Quantity: 0.1 mg

* All prices are quoted net of the statutory value-added tax and shipping costs and possibly delivery charges, if not otherwise described

Need more information?
Need more information?
Service Hotline | Contact | Benefits
Service hotline
0333 320 3460 Mon-Fri, 9 am - 5 pm

Contact
Use our contact form